Description

[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-3-[2-[2-(2-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a high-purity, complex nucleotide derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block or precursor for synthesizing modified nucleic acids and exploring novel enzymatic pathways. It is primarily sought by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in cutting-edge projects related to molecular biology, enzymology, and therapeutic discovery.

Application

• Biochemical Research: As a specialized substrate or inhibitor for studying enzyme kinetics, particularly those involving nucleotide metabolism and transferase activities.
• Pharmaceutical R&D: A key intermediate in the synthesis of novel nucleotide-based prodrugs or potential therapeutic agents targeting viral or cellular polymerases.
• Proteomics & Enzymology: Used in the study of protein-nucleic acid interactions and the mechanism of action of various phosphorylating enzymes.
• Diagnostic Reagent Development: Potential component in the formulation of high-sensitivity assay kits for detecting specific enzymatic activities or biomarkers.
• Antiviral/Anticancer Agent Research: Serves as a structural analog in the design and screening of new compounds with targeted biological activity.
• Academic Research: Fundamental studies in organic synthesis, medicinal chemistry, and the structure-activity relationships of modified nucleosides.

Basic Information

Product Name	[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-3-[2-[2-(2-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	1926-57-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-; dATP (commonly refers to the 2'-deoxy form); 2'-Deoxyadenosine-5'-triphosphate; Deoxyadenosine triphosphate; dATP, free acid; 2'-Deoxy-ATP; Adenosine 5'-(tetrahydrogen triphosphate), 2'-deoxy- (9CI); 1926-57-4
EINECS	Contact for details

Quality Control

Our [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-3-[2-[2-(2-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is produced and handled under strict quality management protocols. The product undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere (e.g., argon or nitrogen) after each use to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 3.0 %
Assay (UV/VIS)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.