Description

1-Chloro-3-(Difluoromethoxy)-2-Methyl-Benzene is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated aromatic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where its difluoromethoxy and chloro substituents serve as key functional handles for further chemical elaboration. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides and pesticides, leveraging its halogenated structure for enhanced biological activity and environmental stability.
• Material Science Research: Used in the development of specialty polymers and liquid crystals, where the difluoromethoxy group can influence material properties like thermal stability and dielectric constant.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new fluorination methodologies and constructing complex aromatic scaffolds.

Basic Information

Product Name	1-Chloro-3-(Difluoromethoxy)-2-Methyl-Benzene
CAS No.	960249-91-6
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	2-Methyl-1-chloro-3-(difluoromethoxy)benzene; 1-Chloro-2-methyl-3-(difluoromethoxy)benzene; 3-(Difluoromethoxy)-2-methylchlorobenzene; Benzene, 1-chloro-3-(difluoromethoxy)-2-methyl-; 960249-91-6; DFMB Chloride Intermediate; Difluoromethoxy Chlorotoluene
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-3-(Difluoromethoxy)-2-Methyl-Benzene adheres to stringent quality management systems. Every batch is analyzed using advanced techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.