Description

3-(Trifluoromethoxy)Fluorobenzene is a versatile fluorinated aromatic building block, valued for its unique combination of a trifluoromethoxy group and fluorine atom which impart significant lipophilicity and metabolic stability. This compound is essential for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where electronic and steric properties are critical. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly for CNS-targeted therapies and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, leveraging the trifluoromethoxy group to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core structure in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where its electronic properties are crucial.
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce fluorinated aromatic motifs into complex molecules.
• Chemical Research & Development: A valuable reagent for exploring new reaction pathways and creating compound libraries in medicinal chemistry.

Basic Information

Product Name	3-(Trifluoromethoxy)Fluorobenzene
CAS No.	1077-01-6
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	1-Fluoro-3-(trifluoromethoxy)benzene; m-(Trifluoromethoxy)fluorobenzene; 3-Fluorophenyl trifluoromethyl ether; α,α,α-Trifluoro-m-fluoroanisole; Benzene, 1-fluoro-3-(trifluoromethoxy)-; 3-Fluoro-1-(trifluoromethoxy)benzene; F3CO-Ph-F
EINECS	214-080-9

Quality Control

Our 3-(Trifluoromethoxy)Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding applications in GMP-influenced synthesis and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and reducing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.35 - 1.40 g/mL
Refractive Index (n20D)	1.390 - 1.400

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.