Description

2-(Trifluoromethyl)Anisole is a versatile fluorinated aromatic building block, valued for its unique combination of an electron-donating methoxy group and an electron-withdrawing trifluoromethyl group. This structural motif makes it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams, as well as production chemists, in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly for central nervous system (CNS) agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Dyes and Pigments: Incorporated into the structure of specialty dyes to alter solubility, lightfastness, and color properties.
• Polymer Modification: Used to introduce fluorine-containing side chains into polymers, improving chemical resistance and surface properties.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for constructing biaryl systems.

Basic Information

Product Name	2-(Trifluoromethyl)Anisole
CAS No.	16222-42-7
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	1-Methoxy-2-(trifluoromethyl)benzene; o-(Trifluoromethyl)anisole; 2-(Trifluoromethyl)methoxybenzene; α,α,α-Trifluoro-o-cresol methyl ether; 2-Methoxybenzotrifluoride; o-Methoxybenzotrifluoride; 2-Trifluoromethylphenyl methyl ether
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.