Description

3-Ethynylpiperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a reactive alkyne functional group. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules through click chemistry and other coupling reactions. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides for bioconjugation and library synthesis.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Incorporated into molecular probes for studying biological targets and pathways.
• Academic & Industrial R&D: Essential for exploratory research in organic synthesis and process chemistry within universities and corporate R&D centers.

Basic Information

Product Name	3-Ethynylpiperidine Hydrochloride
CAS No.	959918-19-5
Molecular Formula	C7H11N·HCl
Molecular Weight	145.63 g/mol
Synonyms	3-Ethynylpiperidine HCl; 3-Ethynylpiperidine Hydrochloride Salt; Piperidine, 3-ethynyl-, hydrochloride; 3-Ethynylpiperidinium chloride; 1-(2-Propynyl)piperidine hydrochloride; 3-(Piperidin-3-ylethynyl) hydrochloride; 959918-19-5
EINECS	Contact for details

Quality Control

Our 3-Ethynylpiperidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.