Description

Rac Metoprolol-D7 CAS NO 959787-96-3 is a deuterium-labeled analog of the widely used β-blocker, metoprolol. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing superior accuracy and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioequivalence testing, and clinical research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the precise quantification of metoprolol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Used as a reference material to develop, optimize, and validate sensitive and specific analytical methods compliant with FDA and EMA guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Facilitates reliable measurement of metoprolol concentrations in patient samples to ensure therapeutic efficacy and safety.
• Forensic and Toxicological Analysis: Employed in forensic laboratories for the definitive identification and quantification of metoprolol in cases of overdose or post-mortem investigations.
• Pharmaceutical Impurity Profiling: Can be used in studies to understand the degradation pathways and stability of metoprolol drug products.

Basic Information

Product Name	Rac Metoprolol-D7
CAS No.	959787-96-3
Molecular Formula	C15H18D7NO3
Molecular Weight	270.39 g/mol (approx.)
Synonyms	Metoprolol-d7; (±)-Metoprolol-d7; DL-Metoprolol-d7; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol-d7; (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol-d7; Lopressor-d7; Toprol-XL-d7; Betaloc-d7
EINECS	Contact for details

Quality Control

Every batch of Rac Metoprolol-D7 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data for identity, purity (HPLC assay), isotopic enrichment, and residual solvents, ensuring traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.