Description

(3R,4R)-Benzyl 4-Amino-3-Hydroxypiperidine-1-Carboxylate is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold with precise stereochemistry, enabling the development of complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potent drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where specific chirality is crucial for efficacy and environmental safety.
• Chemical Biology & Probe Development: Employed as a scaffold for creating molecular probes to study enzyme mechanisms and biological pathways.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Peptidomimetics & Constrained Analogues: Integral for designing conformationally restricted peptide mimics to enhance metabolic stability and receptor selectivity.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	(3R,4R)-Benzyl 4-Amino-3-Hydroxypiperidine-1-Carboxylate
CAS No.	959617-87-9
Molecular Formula	C13H18N2O3
Molecular Weight	250.30 g/mol
Synonyms	1-CBz-(3R,4R)-4-Amino-3-hydroxypiperidine; Benzyl (3R,4R)-4-Amino-3-hydroxypiperidine-1-carboxylate; (3R,4R)-1-[(Benzyloxy)carbonyl]-4-amino-3-piperidinol; (3R,4R)-4-Amino-3-hydroxypiperidine-1-carboxylic acid benzyl ester; 1-N-CBz-(3R,4R)-3,4-Piperidinediol, 4-amino-; (3R,4R)-4-Amino-3-piperidinol 1-carbobenzoxy derivative; BnOCO-(3R,4R)-AHP; (3R-cis)-1-(Phenylmethoxy)carbonyl-4-amino-3-piperidinol
EINECS	Contact for details

Quality Control

Our (3R,4R)-Benzyl 4-Amino-3-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity consistent with pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.