Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-Cinnamylpyrrolidine-2-Carboxylic Acid CAS NO 959584-07-7 is a high-purity, chiral pyrrolidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the development of complex, biologically active molecules, offering a defined stereochemistry that is crucial for achieving desired pharmacological profiles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, including protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in the synthesis of protease inhibitors and other targeted therapies.
• Peptidomimetic Chemistry: Used to construct constrained peptide analogs and peptidomimetics, enhancing metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a versatile scaffold or chiral auxiliary in stereoselective synthesis to introduce complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale for Active Pharmaceutical Ingredient (API) manufacturing.
• Academic Research: A valuable reagent for universities and research institutes studying new synthetic methodologies and catalysis involving chiral amines and carboxylic acids.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-Cinnamylpyrrolidine-2-Carboxylic Acid
CAS No.	959584-07-7
Molecular Formula	C19H25NO4
Molecular Weight	331.41 g/mol
Synonyms	Boc-4-Cinnamyl-D-proline; (2S,4R)-1-Boc-4-cinnamylpyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-2-pyrrolidinecarboxylic acid, (2S,4R)-; 4-Cinnamyl-D-proline tert-butyl ester; (2S,4R)-4-Cinnamyl-1-[(tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid; (2S,4R)-1-(Boc)-4-(cinnamyl)proline; Boc-Cinnamyl-D-pro-OH
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-(tert-Butoxycarbonyl)-4-Cinnamylpyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.