Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a chiral pyrrolidine scaffold and a trifluoromethylbenzyl group. This compound is a critical chiral building block and advanced pharmaceutical intermediate, valued for its role in constructing complex molecules with defined stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting enzymatic pathways.
• Protease Inhibitor Research: Used in the development and scale-up of potential protease inhibitors due to its specific stereochemistry and functional groups.
• Peptidomimetics Construction: Acts as a constrained proline analogue for designing and synthesizing novel peptidomimetic compounds with enhanced metabolic stability.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the impact of the trifluoromethyl group and chiral centers on biological activity.
• Process Chemistry & Route Scouting: Used by process chemists for developing and optimizing scalable synthetic routes to target molecules.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis services catering to the needs of biotechnology and pharmaceutical clients.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959582-85-5
Molecular Formula	C18H22F3NO4
Molecular Weight	373.37 g/mol
Synonyms	1-Boc-4-[(3-(trifluoromethyl)phenyl)methyl]-(2S,4R)-proline; (2S,4R)-1-Boc-4-(3-(Trifluoromethyl)benzyl)pyrrolidine-2-carboxylic acid; (2S,4R)-1-(tert-Butoxycarbonyl)-4-[3-(trifluoromethyl)benzyl]pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[[3-(trifluoromethyl)phenyl]methyl]-(2S,4R)-2-pyrrolidinecarboxylic acid; Boc-(2S,4R)-4-(3-CF3-benzyl)Pro-OH; (2S,4R)-Boc-4-(3-Trifluoromethylbenzyl)proline; (2S,4R)-N-Boc-4-(3-trifluoromethylbenzyl)proline
EINECS	Contact for details

Quality Control

Our production of (2S,4R)-1-(tert-Butoxycarbonyl)-4-(3-(Trifluoromethyl)Benzyl)Pyrrolidine-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.