Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(Naphthalen-1-Ylmethyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a chiral pyrrolidine scaffold with a naphthyl substituent. This compound is a critical advanced pharmaceutical intermediate (API) designed for the synthesis of complex, biologically active molecules. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel therapeutics, including protease inhibitors and other small-molecule drugs.

Application

• Key chiral building block for the synthesis of novel drug candidates targeting various disease pathways.
• Advanced intermediate in the research and process development of protease inhibitors and enzyme modulators.
• Precursor for constructing complex peptidomimetics and constrained peptide analogs in medicinal chemistry.
• Used in asymmetric synthesis to introduce specific stereochemistry into target molecular frameworks.
• Starting material for the development of chemical probes and tools for biochemical and pharmacological research.
• Critical component in custom synthesis and contract manufacturing for the pharmaceutical industry.

Basic Information

Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-(Naphthalen-1-Ylmethyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959582-82-2
Molecular Formula	C22H27NO4
Molecular Weight	369.46 g/mol
Synonyms	Boc-4-(1-Naphthylmethyl)-L-proline; (2S,4R)-1-Boc-4-(1-Naphthylmethyl)pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(1-naphthalenyl)methyl]-2-pyrrolidinecarboxylic acid, (2S,4R)-; (2S,4R)-1-(tert-Butoxycarbonyl)-4-(1-naphthylmethyl)pyrrolidine-2-carboxylic acid; Boc-(2S,4R)-4-(1-Naphthylmethyl)proline; (2S,4R)-Boc-4-(1-Naphthalenylmethyl)proline; (2S,4R)-1-Boc-4-(naphthalen-1-ylmethyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.