Description

Boc-(Trans)-4-(3-Bromo-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a chemically defined, stereochemically pure scaffold for constructing complex molecules, enabling precise control over the final product's architecture. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce a rigid, substituted pyrrolidine ring system into peptide backbones to enhance metabolic stability and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the synthesis of advanced, biologically active compounds for crop protection.
• Chemical Biology Probes: Utilized to build molecular tools for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific stereochemistry and functionalization.

Basic Information

Product Name	Boc-(Trans)-4-(3-Bromo-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959582-16-2
Molecular Formula	C16H20BrNO4
Molecular Weight	370.24 g/mol
Synonyms	(3R,4R)-1-tert-Butoxycarbonyl-4-(3-bromophenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-4-(3-Bromophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; trans-1-Boc-4-(3-bromophenyl)pyrrolidine-3-carboxylic acid; Boc-4-(3-Br-Ph)-Pro-OH(trans); tert-Butyl (3R,4R)-4-(3-bromophenyl)-3-(carboxy)pyrrolidine-1-carboxylate; 959582-16-2; Boc-(3-Bromo-Phenyl)-Pro-OH (trans)
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(3-Bromo-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.