Description

n-Boc-(2S,3S)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a chiral β-hydroxy-α-amino acid scaffold with a Boc-protected amine and a trifluoromethylphenyl side chain. This compound matters as a critical chiral building block for medicinal chemistry, enabling the synthesis of complex molecules with enhanced metabolic stability and binding affinity due to the presence of the trifluoromethyl group. It is primarily needed by pharmaceutical R&D and process chemistry teams for developing novel protease inhibitors, peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies.
• Peptidomimetic Synthesis: Used to incorporate a constrained, non-proteinogenic amino acid residue into peptide backbones to improve stability and pharmacological properties.
• Protease Inhibitor Development: Serves as a core structural element in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology & Probe Design: Employed in creating activity-based probes and labeled compounds for studying enzyme function and mechanism.
• Process Chemistry & Scale-Up: Suitable for use in route scouting and optimization for the commercial-scale manufacturing of advanced intermediates.
• Academic Research: Utilized in university and institutional labs for studies in asymmetric synthesis, organofluorine chemistry, and medicinal chemistry.

Basic Information

Product Name	n-Boc-(2S,3S)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	959582-10-6
Molecular Formula	C15H18F3NO5
Molecular Weight	349.30 g/mol
Synonyms	(2S,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propanoic acid; Boc-Thr(4-CF3Ph)-OH; tert-Butyl (1S,2S)-1-carboxy-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propylcarbamate; (2S,3S)-2-Hydroxy-3-[(tert-butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]propionic acid; N-Boc-3-amino-2-hydroxy-3-(4-trifluoromethylphenyl)propionic acid; (2S,3S)-N-Boc-3-Amino-2-hydroxy-3-(4-trifluoromethylphenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Boc-(2S,3S)-3-Amino-2-Hydroxy-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.