Description

1-Hydroxybenzotriazole Hydrate is a versatile and highly effective peptide coupling reagent and catalyst. This compound is critical for facilitating amide bond formation in organic synthesis, particularly in peptide chemistry, by suppressing racemization and enhancing reaction yields. It is an essential raw material for pharmaceutical R&D, agrochemical production, and advanced material science applications requiring high-purity intermediates.

Application

• Peptide Synthesis: A key additive in solid-phase and solution-phase peptide synthesis to minimize racemization during coupling steps.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Agrochemical Production: Employed as a catalyst or reagent in the manufacture of pesticides and herbicides.
• Bioconjugation: Facilitates the coupling of peptides to proteins, antibodies, or other biomolecules for research and diagnostic applications.
• Polymer Chemistry: Acts as a catalyst in the synthesis of polyamides and other specialty polymers.
• Chemical Research: A standard reagent in organic chemistry laboratories for amide and ester formation.

Basic Information

Product Name	1-Hydroxybenzotriazole Hydrate
CAS No.	123333-53-9
Molecular Formula	C6H5N3O · xH2O
Molecular Weight	135.12 (Anhydrous basis)
Synonyms	HOBt Hydrate; 1-Hydroxy-1H-benzotriazole Hydrate; 1-Hydroxybenzotriazole Monohydrate; Hydroxybenzotriazole; 1-HOBt; HOBT·H2O; Coupling Reagent HOBt; 1-Hydroxybenzotriazole Water Adduct
EINECS	Contact for details

Quality Control

Our 1-Hydroxybenzotriazole Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and KF for water content, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	10.0% - 15.0%
Melting Point	156°C - 165°C (decomposition)
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.