Description

4-Chloro-D-Tryptophan is a halogenated derivative of the essential amino acid tryptophan, featuring a chlorine substituent at the 4-position of the indole ring and the D-configuration. This specific chiral modification makes it a valuable non-natural amino acid building block for advanced research and synthesis. It is particularly sought after for the development of novel peptides and bioactive compounds in pharmaceutical discovery. This high-purity intermediate is essential for researchers and manufacturers in the life sciences and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies and metabolic pathway investigations due to its modified indole structure.
• Peptide Synthesis: Serves as a protected or unprotected building block in solid-phase and solution-phase peptide synthesis (SPPS) to introduce unique properties.
• Proteomics & Labeling: Potential utility in mass spectrometry tags or as a stable isotope-labeled (e.g., 13C, 15N) internal standard for quantitative proteomic analysis.
• Neuroscience Research: Investigated for its effects on serotonin biosynthesis and related neurological pathways as a tryptophan analog.
• Fine Chemical Synthesis: Employed in the asymmetric synthesis of complex natural products and other chiral molecules requiring the D-tryptophan scaffold.

Basic Information

Product Name	4-Chloro-D-Tryptophan
CAS No.	27542-41-2
Molecular Formula	C11H11ClN2O2
Molecular Weight	238.67 g/mol
Synonyms	D-4-Chlorotryptophan; (R)-2-Amino-3-(4-chloro-1H-indol-3-yl)propanoic acid; 4-Chloro-D-tryptophan; 4-Cl-D-Trp; 4-Chloro-(R)-tryptophan; 4-Chlorotryptophan, D-; 4-Chloroindole-3-alanine, D-; (R)-4-Chlorotryptophan
EINECS	Contact for details

Quality Control

Our 4-Chloro-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures material suitable for demanding research and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.