Description

(R)-n-Fmoc-4-Bromophenylalanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is a critical chiral building block, enabling the precise introduction of a brominated aromatic side chain with defined stereochemistry into complex molecular architectures. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based drug candidates, PROTACs, and other bioactive molecules where structural control and functional group manipulation are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing bromophenylalanine residues.
• Pharmaceutical Intermediates: Serves as a crucial chiral precursor in the research and development of novel therapeutic agents, including oncology and metabolic disorder treatments.
• Peptidomimetic Design: Used to create stable peptide analogs with enhanced bioavailability and receptor binding affinity.
• Chemical Biology Probes: Incorporation into peptides for studying protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• PROTAC (Proteolysis Targeting Chimera) Development: Acts as a versatile linker component or a functionalized moiety in the construction of heterobifunctional degraders.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced biomaterials with specific optical or electronic properties.

Basic Information

Product Name	(R)-n-Fmoc-4-Bromophenylalanine
CAS No.	198545-76-5
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-4-Bromo-D-phenylalanine; Fmoc-p-Bromo-D-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-bromo-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-bromophenyl)propanoic acid; Fmoc-D-4-Br-Phe-OH; Fmoc-4-Br-D-Phe-OH; N-α-Fmoc-4-bromo-D-phenylalanine; Boc-D-4-Bromophenylalanine (Note: This is a common related compound, often searched in error)
EINECS	Contact for details

Quality Control

Our (R)-n-Fmoc-4-Bromophenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.