Description

Fmoc-Ser(Tbu)-Thr(Psime,Mepro)-Oh CAS NO 1266350-99-5 is a specialized, orthogonally protected dipeptide building block designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity during the assembly of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of peptide chains on resin supports.
• Therapeutic Peptide Development: Enables the synthesis of complex peptide sequences for drug discovery targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Research: Serves as a building block for creating modified peptide analogs with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation and Labeling: The Fmoc-protected N-terminus and protected side-chains allow for selective deprotection and attachment of fluorescent tags, affinity handles, or other functional groups.
• Combinatorial Chemistry Libraries: Used in the automated generation of diverse peptide libraries for high-throughput screening.
• Academic and Industrial Research: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Thr(Psime,Mepro)-Oh
CAS No.	1266350-99-5
Molecular Formula	C33H46N2O8Si
Molecular Weight	626.82 g/mol
Synonyms	Fmoc-Ser(tBu)-Thr[Psi(Me,Pro)]-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-seryl-N-[(2S,3R)-3-hydroxy-1-[(2S)-1-methylpyrrolidin-2-yl]-1-oxobutan-2-yl]-L-threoninamide; Fmoc-Ser(tBu)-Thr[ψ(Me,Pro)]-OH; Fmoc-L-Serine(O-tert-butyl)-L-threonine[ψ(Me,Pro)] pseudodipeptide; Fmoc-Ser(O-tBu)-Thr[Psi(Me,Pro)]-OH; Fmoc-Ser(Trt)-Thr(Psime,Mepro)-Oh (common variant naming); Fmoc-Ser(tBu)-Thr(ψ[CH(Me)N(Pro)])-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of Fmoc-Ser(Tbu)-Thr(Psime,Mepro)-Oh is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the production of materials intended for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (by anhydrous basis)
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.