Description

Boc-(Trans)-4-(2-Fluoro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in the precise stereochemistry and functional groups that enable the efficient construction of complex molecular architectures, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who are developing novel therapeutic agents, especially those targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for neurological and psychiatric disorders.
• Peptidomimetic Design: Used to incorporate constrained, fluorinated proline analogs into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Asymmetric Synthesis Catalyst Ligand: The scaffold can be utilized to develop novel chiral ligands for asymmetric catalysis.
• Chemical Biology Probe Development: Serves as a building block for creating activity-based probes or labeled compounds to study enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for optimizing synthetic routes from milligram to kilogram scale during API development.

Basic Information

Product Name	Boc-(Trans)-4-(2-Fluoro-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959581-02-3
Molecular Formula	C₁₆H₂₀FNO₄
Molecular Weight	309.34 g/mol
Synonyms	(3R,4R)-1-tert-Butoxycarbonyl-4-(2-fluorophenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-1-(tert-Butoxycarbonyl)-4-(2-fluorophenyl)-3-pyrrolidinecarboxylic acid; trans-1-Boc-4-(2-fluorophenyl)-3-pyrrolidinecarboxylic acid; (3R,4R)-4-(2-Fluorophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; 1-N-Boc-4-(2-fluorophenyl)-3-pyrrolidinecarboxylic acid; Boc-trans-4-(2-Fluorophenyl)-D,L-proline derivative; 959581-02-3
EINECS	Contact for details

Quality Control

Every batch of Boc-(Trans)-4-(2-Fluoro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in cGMP environments, and we provide full traceability and documentation. Certificates of Analysis (COA) detailing purity (typically ≥97% by HPLC), chiral purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.