Description

Boc-(Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the construction of complex molecules with defined stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel drug candidates and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Peptidomimetics & Constrained Peptides: Used to introduce a rigid, substituted pyrrolidine scaffold into peptide backbones to enhance metabolic stability and receptor selectivity.
• Combinatorial Chemistry Libraries: Employed in the solid-phase and solution-phase synthesis of diverse compound libraries for high-throughput screening (HTS) against biological targets.
• Asymmetric Synthesis: Acts as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and protein-protein interactions.
• Academic & Contract Research: Serves as a valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology development and medicinal chemistry projects.

Basic Information

Product Name	Boc-(Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959580-91-7
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	(3R,4S)-1-tert-Butyl 3-methyl 4-(3,4-dimethoxyphenyl)pyrrolidine-1,3-dicarboxylate; (3R,4S)-4-(3,4-Dimethoxyphenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; tert-Butyl (3R,4S)-4-(3,4-dimethoxyphenyl)-3-(methoxycarbonyl)pyrrolidine-1-carboxylate; Boc-4-(3,4-Dimethoxyphenyl)-D-proline methyl ester derivative; trans-N-Boc-4-(3,4-Dimethoxyphenyl)proline-3-carboxylic acid; (3R,4S)-1-(tert-Butoxycarbonyl)-4-(3,4-dimethoxyphenyl)pyrrolidine-3-carboxylic acid; 959580-91-7
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.