Description

Boc-(Trans)-4-(3-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the construction of complex molecular architectures with precise stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged molecules used in target identification and mechanism-of-action studies.
• Library Synthesis for Drug Discovery: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening (HTS).
• Asymmetric Catalysis Ligand Precursor: Can be utilized in the synthesis of novel chiral ligands for asymmetric hydrogenation and other catalytic transformations.

Basic Information

Product Name	Boc-(Trans)-4-(3-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959580-33-7
Molecular Formula	C17H20N2O4
Molecular Weight	316.36 g/mol
Synonyms	(3R,4R)-1-(tert-Butoxycarbonyl)-4-(3-cyanophenyl)pyrrolidine-3-carboxylic Acid; (3R,4R)-1-Boc-4-(3-cyanophenyl)pyrrolidine-3-carboxylic Acid; trans-1-Boc-4-(3-cyanophenyl)-3-pyrrolidinecarboxylic Acid; (3R,4R)-4-(3-Cyanophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic Acid; 959580-33-7; Boc-trans-4-(3-Cyanophenyl)pyrrolidine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(3-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, NMR, and MS data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.