Description

Boc-(Trans)-4-(4-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically defined pyrrolidine scaffold with orthogonal protecting groups, enabling precise construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring constrained peptidomimetics or specific three-dimensional pharmacophores.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and oncology targets.
• Peptidomimetic Scaffold: Used to construct conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Agrochemical Synthesis: Building block for creating novel herbicides or fungicides with specific chiral activity.
• Chemical Biology Probes: Incorporation into molecular probes for studying enzyme function or protein-protein interactions.
• Asymmetric Catalysis Ligand Precursor: Potential precursor for chiral ligands used in asymmetric hydrogenation or cross-coupling reactions.
• Academic & Contract Research: Fundamental research tool in synthetic organic chemistry for methodology development and complex natural product synthesis.

Basic Information

Product Name	Boc-(Trans)-4-(4-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959579-94-3
Molecular Formula	C16H20N2O6
Molecular Weight	336.34 g/mol
Synonyms	(3R,4R)-1-tert-Butoxycarbonyl-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-1-Boc-4-(4-nitrophenyl)pyrrolidine-3-carboxylic acid; trans-1-Boc-4-(4-nitrophenyl)-3-pyrrolidinecarboxylic acid; (3R,4R)-4-(4-Nitrophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; tert-Butyl (3R,4R)-3-carboxy-4-(4-nitrophenyl)pyrrolidine-1-carboxylate; Boc-trans-4-(4-NO2-Ph)-Pro-3-COOH; 959579-94-3
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(4-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral HPLC data, and spectroscopic identification is supplied with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (trans isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.