Description

Boc-(S)-α-(3-Phenyl-Propyl)-Proline is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and a chiral proline core. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control for advanced pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in peptide-based therapeutics.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs that mimic natural peptide structures with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core scaffold or side-chain component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms through the incorporation of modified amino acids.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific chiral motif.
• Academic Research: A valuable reagent for universities and research institutes exploring novel synthetic methodologies and bioactive compound libraries.

Basic Information

Product Name	Boc-(S)-α-(3-Phenyl-Propyl)-Proline
CAS No.	959579-73-8
Molecular Formula	C20H29NO4
Molecular Weight	347.45 g/mol
Synonyms	(S)-1-[(tert-Butoxy)carbonyl]-2-(3-phenylpropyl)proline; Boc-(S)-3-Phenylpropyl-Pro-OH; (S)-1-Boc-2-(3-phenylpropyl)proline; N-Boc-(S)-α-(3-Phenylpropyl)proline; tert-Butyl (2S)-2-(3-phenylpropyl)prolinate-1-carboxylate; (S)-N-Boc-α-(3-Phenylpropyl)proline; 1-Boc-2-(3-phenylpropyl)-(S)-proline
EINECS	Contact for details

Quality Control

Our Boc-(S)-α-(3-Phenyl-Propyl)-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.