Description

Boc-(Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical chiral building block in the synthesis of complex molecules, offering precise stereochemical control. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Synthesis: Used to incorporate constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Utilized as a building block for developing novel crop protection agents with specific stereochemical requirements.

Basic Information

Product Name	Boc-(Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959579-54-5
Molecular Formula	C16H20N2O4
Molecular Weight	304.34 g/mol
Synonyms	(3R,4S)-1-(tert-Butoxycarbonyl)-4-(pyridin-4-yl)pyrrolidine-3-carboxylic acid; (3R,4S)-4-(4-Pyridinyl)-1-[(1,1-dimethylethoxy)carbonyl]-3-pyrrolidinecarboxylic acid; tert-Butyl (3R,4S)-3-carboxy-4-(4-pyridyl)pyrrolidine-1-carboxylate; Boc-trans-4-(4-Pyridyl)-D-proline; Boc-4-(4-Pyridyl)-D-proline; Boc-(3R,4S)-4-(4-Pyridinyl)pyrrolidine-3-carboxylic acid; 959579-54-5
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(4-Pyridinyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure identity, purity, and enantiomeric excess meet rigorous standards. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.