Description

(2S,4R)-4-({[1,1'-Biphenyl]-4-Yl}Methyl)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a biphenylmethyl side chain and an Fmoc-protected pyrrolidine carboxylic acid core. This compound is a critical building block (Fmoc-protected amino acid) for solid-phase peptide synthesis (SPPS), enabling the precise incorporation of constrained, hydrophobic motifs into complex peptide sequences. It is essential for researchers and manufacturers in pharmaceutical R&D and biotechnology developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Key precursor in the research and development of novel peptide drugs targeting GPCRs, enzymes, and protein-protein interactions.
• Peptidomimetic Design: Incorporation into designed peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used as tools for studying biological pathways and mechanisms.
• API Development: Intermediate in the synthetic route for Active Pharmaceutical Ingredients (APIs) with complex peptide architectures.
• Academic & Contract Research: Essential reagent for universities and CROs conducting cutting-edge research in medicinal chemistry and biochemistry.

Basic Information

Product Name	(2S,4R)-4-({[1,1'-Biphenyl]-4-Yl}Methyl)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid
CAS No.	959578-04-2
Molecular Formula	C37H33NO4
Molecular Weight	555.67 g/mol
Synonyms	Fmoc-(2S,4R)-4-([1,1'-Biphenyl]-4-ylmethyl)pyrrolidine-2-carboxylic acid; Fmoc-4-Biphenylmethyl-Pro-OH (trans-4-substituted); (2S,4R)-Fmoc-4-(Biphenyl-4-ylmethyl)proline; 1-Fmoc-4-[(1,1'-biphenyl-4-yl)methyl]-L-proline; Fmoc-trans-4-Biphenylmethyl-L-proline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-([1,1'-biphenyl]-4-ylmethyl)-L-proline; Fmoc-4-Biphenylmethyl-trans-L-proline; Biphenylmethyl-Fmoc-proline derivative
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-({[1,1'-Biphenyl]-4-Yl}Methyl)-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for reproducible peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.