Description

Boc-(Trans)-4-(3-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a chiral pyrrolidine scaffold. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex, biologically active molecules with precise stereochemistry. It is primarily needed by R&D and production teams in the pharmaceutical, biotechnology, and agrochemical sectors for developing new drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Synthesis: Serves as a core structural component in the design and synthesis of protease inhibitors due to its pyrrolidine carboxylic acid moiety.
• Peptidomimetic Chemistry: Used to construct peptidomimetics and conformationally constrained peptides for drug discovery programs.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Agrochemical Research: Acts as a precursor in the development of new herbicides and pesticides with specific chiral activity.
• Chemical Biology Probes: Utilized for creating labeled compounds and molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	Boc-(Trans)-4-(3-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	959577-50-5
Molecular Formula	C16H20N2O6
Molecular Weight	336.34 g/mol
Synonyms	(3R,4R)-1-[(tert-Butoxy)carbonyl]-4-(3-nitrophenyl)-3-pyrrolidinecarboxylic acid; (3R,4R)-1-Boc-4-(3-nitrophenyl)pyrrolidine-3-carboxylic acid; tert-Butyl (3R,4R)-3-carboxy-4-(3-nitrophenyl)pyrrolidine-1-carboxylate; trans-1-Boc-4-(3-nitrophenyl)pyrrolidine-3-carboxylic acid; Boc-trans-4-(3-Nitrophenyl)pyrrolidine-3-carboxylic Acid; 959577-50-5; 1-Boc-4-(3-NO2-Ph)-pyrrolidine-3-COOH
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(3-Nitro-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting R&D and cGMP standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.