Description

Ethyl 1-(4-Fluorophenyl)-5-Iodo-1H-Pyrazole-4-Carboxylate is a high-purity, functionalized pyrazole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its unique molecular architecture, combining a fluorinated aromatic ring with an iodinated pyrazole core, which makes it an essential building block for constructing complex pharmacophores and agrochemicals. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and for use in cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated pyrazole structure.
• Material Science: Serves as a precursor for the synthesis of specialized ligands, organic semiconductors, and liquid crystals.
• Cross-Coupling Reactions: The iodine atom at the 5-position makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to create diverse chemical libraries.
• Chemical Biology: Utilized as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Item	Detail
Product Name	Ethyl 1-(4-Fluorophenyl)-5-Iodo-1H-Pyrazole-4-Carboxylate
CAS No.	959576-71-7
Molecular Formula	C12H10FINO2
Molecular Weight	360.12 g/mol
Synonyms	Ethyl 5-Iodo-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate; 1-(4-Fluorophenyl)-5-iodo-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 5-Iodo-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 959576-71-7; 1H-Pyrazole-4-carboxylic acid, 1-(4-fluorophenyl)-5-iodo-, ethyl ester; Ethyl 1-(p-fluorophenyl)-5-iodopyrazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 1-(4-Fluorophenyl)-5-Iodo-1H-Pyrazole-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.