Description

(2S,4S)-1-(tert-Butoxycarbonyl)-4-(Thiophen-2-Ylmethyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a chiral pyrrolidine scaffold protected by a Boc (tert-butoxycarbonyl) group. This compound is a critical chiral building block and advanced pharmaceutical intermediate, valued for its role in constructing complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas like protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for protease-targeted therapies.
• Peptidomimetic Research: Used to introduce constrained, chiral proline-like structures into peptide backbones to enhance metabolic stability and binding affinity.
• Medicinal Chemistry: Acts as a versatile building block for constructing compound libraries in drug discovery and lead optimization programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• Bioconjugation: The carboxylic acid functionality allows for coupling to other molecules, useful in creating targeted drug conjugates or probes.
• Academic & R&D: Used in university and institutional research for studying structure-activity relationships and novel synthetic methodologies.

Basic Information

Product Name	(2S,4S)-1-(tert-Butoxycarbonyl)-4-(Thiophen-2-Ylmethyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959575-44-1
Molecular Formula	C16H23NO4S
Molecular Weight	325.42 g/mol
Synonyms	Boc-4-(2-Thienylmethyl)-L-proline; (2S,4S)-1-Boc-4-(Thiophen-2-ylmethyl)pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(2-thienyl)methyl]-2-pyrrolidinecarboxylic acid, (2S,4S)-; (2S,4S)-1-(tert-Butoxycarbonyl)-4-(thiophen-2-ylmethyl)pyrrolidine-2-carboxylic acid; (2S,4S)-4-(Thiophen-2-ylmethyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester; Boc-(2S,4S)-4-(2-Thienylmethyl)proline; (2S,4S)-Boc-4-(2-Thienylmethyl)proline
EINECS	Contact for details

Quality Control

Our (2S,4S)-1-(tert-Butoxycarbonyl)-4-(Thiophen-2-Ylmethyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.