Description

1,5-Benzoxazepine-5(2H)-Acetic Acid, 3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-3,4-Dihydro-4-Oxo-, (3S)- is a sophisticated chiral building block and protected amino acid derivative of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key intermediate for the synthesis of complex, biologically active molecules, particularly in the field of peptide mimetics and targeted drug discovery. This high-purity compound is essential for medicinal chemists and process development scientists working on novel therapeutic agents, including protease inhibitors and other enzyme-targeted drugs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used in constructing non-natural amino acid scaffolds to enhance the metabolic stability and bioavailability of peptide-based drug candidates.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various protease enzymes, a major target class in drug discovery.
• Chemical Biology & Bioconjugation: Employed in the synthesis of probes and tools for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale manufacturing of complex target molecules.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical suppliers offering bespoke synthesis services to the biopharma industry.

Basic Information

Product Name	1,5-Benzoxazepine-5(2H)-Acetic Acid, 3-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-3,4-Dihydro-4-Oxo-, (3S)-
CAS No.	959574-95-9
Molecular Formula	C26H22N2O6
Molecular Weight	458.47 g/mol
Synonyms	(3S)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,4-dihydro-4-oxo-1,5-benzoxazepine-5(2H)-acetic acid; Fmoc-3-amino-1,5-benzoxazepin-4-one-5-acetic acid (3S); (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-2,3-dihydro-1,5-benzoxazepine-5(4H)-acetic acid; Fmoc-Abz-OH derivative; Protected 1,5-Benzoxazepine amino acid; Chiral benzoxazepine scaffold; CAS 959574-95-9
EINECS	Contact for details

Quality Control

Our 1,5-Benzoxazepine-5(2H)-Acetic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.