Description

(2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-Cyanobenzyl)Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a stereochemically defined pyrrolidine scaffold. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptidomimetics, protease inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core structure for designing inhibitors of various proteolytic enzymes.
• Chemical Biology Research: Employed as a tool compound for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations.
• API Synthesis: Incorporated into the final structure of advanced pharmaceutical ingredients requiring specific stereochemistry.

Basic Information

Item	Details
Product Name	(2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-Cyanobenzyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	959573-33-2
Molecular Formula	C18H22N2O4
Molecular Weight	330.38 g/mol
Synonyms	Boc-4-(2-Cyanobenzyl)-D-proline; (2S,4R)-1-Boc-4-(2-cyanobenzyl)pyrrolidine-2-carboxylic acid; 1-[(1,1-Dimethylethoxy)carbonyl]-4-[(2-cyanophenyl)methyl]-2-pyrrolidinecarboxylic acid, (2S,4R)-; (2S,4R)-1-(Boc)-4-(2-Cyanobenzyl)proline; 959573-33-2; Boc-D-4-(2-Cyanobenzyl)proline
EINECS	Contact for details

Quality Control

Our (2S,4R)-1-(tert-Butoxycarbonyl)-4-(2-Cyanobenzyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.