Description

(4R)-5-[4-(tert-Butoxy)Phenyl]-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is a high-purity, non-natural amino acid derivative featuring orthogonal protecting groups. This compound matters as a critical chiral building block for the controlled synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and bioactive molecules.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid building block for the automated synthesis of complex peptide sequences, where the Fmoc group allows for selective deprotection.
• Peptidomimetic Design: Used to introduce specific structural motifs and side-chain functionalities in the design of metabolically stable peptide analogs.
• Chemical Biology Research: Employed in the synthesis of labeled peptides or peptide probes for studying protein-protein interactions and enzyme mechanisms.
• Custom Synthesis Services: A valuable starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(4R)-5-[4-(tert-Butoxy)Phenyl]-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid
CAS No.	959573-04-7
Molecular Formula	C30H33NO5
Molecular Weight	487.59 g/mol
Synonyms	Fmoc-D-4-tert-Butoxyphenylalanine-OH; Fmoc-D-4-(tert-Butoxy)Phe-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(tert-butoxy)-D-phenylalanine; Fmoc-D-Phe(4-OtBu)-OH; Nα-Fmoc-4-tert-butoxy-D-phenylalanine; D-4-tert-Butoxyphenylalanine, N-Fmoc derivative; CAS 959573-04-7
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR (1H & 13C) for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, ensuring full traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.