Description

1-Benzhydryl-3-Chloroazetidine is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained azetidine scaffold.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the pilot and commercial-scale synthesis of complex molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	1-Benzhydryl-3-Chloroazetidine
CAS No.	959256-87-2
Molecular Formula	C16H16ClN
Molecular Weight	257.76 g/mol
Synonyms	3-Chloro-1-(diphenylmethyl)azetidine; 1-(Chloromethyl)-N-(diphenylmethyl)azetidine; 1-(Diphenylmethyl)-3-chloroazetidine; Benzhydryl-3-chloroazetidine; Azetidine, 3-chloro-1-(diphenylmethyl)-; 959256-87-2; 1-(Diphenylmethyl)azetidin-3-yl chloride
EINECS	Contact for details

Quality Control

Our 1-Benzhydryl-3-Chloroazetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.