Description

Methyl 4-n-Boc-Morpholine-3-Acetate is a high-purity, protected morpholine derivative widely used as a key synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a versatile, reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the fields of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the design and construction of complex molecular libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: Serves as a constrained amino acid surrogate for creating peptide analogs with enhanced metabolic stability and bioavailability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a precursor for synthesizing tool compounds and probes to study biological pathways and target engagement.
• Process Chemistry & Scale-Up: A validated intermediate for the kilogram-scale production of development compounds under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Methyl 4-n-Boc-Morpholine-3-Acetate
CAS No.	959246-85-6
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	Methyl 4-(tert-butoxycarbonyl)morpholine-3-acetate; 3-(Methoxycarbonylmethyl)-4-Boc-morpholine; 4-Boc-3-carboxymethylmorpholine methyl ester; Methyl (4-((tert-butoxycarbonyl)amino)morpholin-3-yl)acetate; tert-Butyl 3-(2-methoxy-2-oxoethyl)morpholine-4-carboxylate; 959246-85-6; Boc-Morpholine-3-Acetic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-n-Boc-Morpholine-3-Acetate is manufactured and tested under a strict quality management system to ensure consistency and reliability for your critical research and development projects. Our products undergo rigorous quality testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request, providing full traceability and supporting regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.