Description

1-Isopropylazetidine-3-Carboxylic Acid is a high-purity, non-natural azetidine derivative that serves as a critical chiral building block in advanced organic synthesis. This compound matters for its unique constrained ring structure and functional group handles, enabling the development of novel molecular architectures with enhanced biological and physical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the creation of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry: Used to introduce the rigid, polar azetidine scaffold into lead compounds to modulate pharmacokinetic properties like solubility, metabolic stability, and bioavailability.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, auxiliaries, or catalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or insecticides where the azetidine ring can confer unique modes of action.
• Chemical Biology: Useful as a molecular probe or a component in bioconjugation reagents due to its carboxylic acid functionality.
• Material Science: Potential monomer or additive for creating specialized polymers with tailored thermal or mechanical properties.

Basic Information

Product Name	1-Isopropylazetidine-3-Carboxylic Acid
CAS No.	959238-28-9
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	3-Azetidinecarboxylic acid, 1-(1-methylethyl)-; 1-Isopropyl-3-carboxyazetidine; Azetidine-3-carboxylic acid, 1-isopropyl-; 1-(Propan-2-yl)azetidine-3-carboxylic acid; 1-Isopropylazetidine-3-carboxylic acid; (1-Isopropylazetidin-3-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Isopropylazetidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic characterization are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.