Description

4-Bromo-2-tert-Butylthiazole is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the thiazole core's bioactivity.
• Material Science Research: Acts as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials due to its bromine substituent for further coupling reactions.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and activity-based protein profiling (ABPP) agents to study biological pathways.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to create more complex molecular architectures.
• Ligand and Catalyst Development: Utilized in the preparation of novel nitrogen-sulfur (N,S) donor ligands for transition metal catalysis.

Basic Information

Product Name	4-Bromo-2-tert-Butylthiazole
CAS No.	959238-21-2
Molecular Formula	C7H10BrNS
Molecular Weight	220.13 g/mol
Synonyms	4-Bromo-2-(1,1-dimethylethyl)thiazole; 2-tert-Butyl-4-bromothiazole; 4-Bromo-2-(tert-butyl)thiazole; 4-Bromo-2-(2-methyl-2-propanyl)-1,3-thiazole; Thiazole, 4-bromo-2-(1,1-dimethylethyl)-; 959238-21-2; 4-Bromo-2-tert-butyl-thiazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-tert-Butylthiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.