Description

n-Fmoc-3-Azetidine Acetic Acid CAS NO 959236-89-6 is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical building block for introducing the constrained, nitrogen-containing azetidine ring system into target molecules, enabling the exploration of novel bioactive structures. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs focused on developing new therapeutic candidates, particularly in areas requiring precise structural control and modified peptide backbones.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides containing the azetidine moiety.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of peptidomimetics and constrained peptides to improve metabolic stability, bioavailability, and target selectivity.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse compound libraries for high-throughput screening against biological targets.
• Bioconjugation: The carboxylic acid functionality allows for coupling to other molecules, such as fluorescent tags, polymers, or carrier proteins, for probe or conjugate development.
• Academic Research: Employed in studies investigating the structure-activity relationships (SAR) of peptides and the physicochemical properties imparted by the azetidine ring.
• Process Development & Scale-Up: Sourced by manufacturers for developing robust synthetic routes to azetidine-containing active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-Fmoc-3-Azetidine Acetic Acid
CAS No.	959236-89-6
Molecular Formula	C₂₁H₂₁NO₄
Molecular Weight	351.40 g/mol
Synonyms	Fmoc-Aze-OH; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,3-azetidineacetic Acid; 1,3-Azetidinediacetic Acid, 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-; 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1,3-azetidinediacetic Acid; Fmoc-3-aminoazetidine-3-acetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidineacetic Acid; (Azetidine-3-acetic acid)-N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-Azetidine Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.