Description

Erythromycin-D6 is a stable isotope-labeled analog of the macrolide antibiotic erythromycin, where six hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise and accurate quantification of erythromycin in complex biological matrices using advanced analytical techniques. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for pharmacokinetic and toxicokinetic studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry assays to track erythromycin absorption, distribution, metabolism, and excretion (ADME).
• Clinical Research: Enables accurate measurement of erythromycin concentrations in patient plasma, serum, or tissue samples during clinical trials.
• Veterinary Pharmaceutical Analysis: Applied in residue testing and pharmacokinetic studies of erythromycin in animal-derived products.
• Environmental Monitoring: Facilitates the detection and quantification of erythromycin antibiotic residues in environmental water samples.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in regulatory-compliant laboratories.
• Quality Control (QC) Testing: Used as a reference standard in pharmaceutical QC labs to ensure the potency and purity of erythromycin-based drug products.

Basic Information

Item	Detail
Product Name	Erythromycin-D6
CAS No.	959119-25-6
Molecular Formula	C37H61D6NO13
Molecular Weight	~ 739.0 g/mol
Synonyms	Erythromycin (hexadeutero); Erythromycin-d6; (3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione-d6; Deuterated Erythromycin; Erythromycin Internal Standard
EINECS	Contact for details

Quality Control

Our Erythromycin-D6 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and identification is provided to ensure compliance with research and method validation standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.