Description

1H-Imidazole-2-Carboxaldehyde, 5-(2-Aminoethyl)- is a specialized bifunctional organic building block featuring both an aldehyde and a primary amine group on an imidazole core. This unique structure makes it a critical intermediate for synthesizing complex heterocyclic compounds, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working in drug discovery, agrochemicals, and advanced material science.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of novel drug candidates, especially kinase inhibitors, histamine H3 receptor antagonists, and other bioactive heterocycles.
• Agrochemical Synthesis: Used in the development of new fungicides, herbicides, and plant growth regulators that require the imidazole pharmacophore.
• Ligand and Chelator Development: Serves as a starting material for creating complexing agents and ligands used in catalysis and metal ion sequestration.
• Bioconjugation and Linker Chemistry: The reactive aldehyde and amine groups enable its use in cross-linking and bioconjugation strategies for antibody-drug conjugates (ADCs) or diagnostic probes.
• Material Science Research: Building block for organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs) due to its electron-rich imidazole ring.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tags for studying enzymatic processes.

Basic Information

Product Name	1H-Imidazole-2-Carboxaldehyde, 5-(2-Aminoethyl)-
CAS No.	959055-98-2
Molecular Formula	C6H9N3O
Molecular Weight	139.16 g/mol
Synonyms	5-(2-Aminoethyl)-1H-imidazole-2-carboxaldehyde; 2-Formyl-5-(2-aminoethyl)imidazole; 1H-Imidazole-2-carboxaldehyde, 5-(2-aminoethyl)-; 5-(2-Aminoethyl)imidazole-2-carbaldehyde; 2-Carboxyaldehyde-5-(2-aminoethyl)imidazole; 5-(2-Aminoethyl)-2-formylimidazole; 2-Formyl-5-(2-aminoethyl)-1H-imidazole
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-2-Carboxaldehyde, 5-(2-Aminoethyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP production for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.