Description

1H-Imidazole-2-Propanoic Acid, α-Hydroxy- is a high-purity, functionalized imidazole derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a hydroxyl group on the imidazole-propanoic acid backbone, makes it invaluable for constructing complex molecules with specific biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly in protease inhibitor and enzyme-targeted therapies.
• Agrochemical Synthesis: Building block for creating advanced fungicides, herbicides, and plant growth regulators with enhanced specificity.
• Bioconjugation & Ligand Design: Used in the synthesis of chelating agents, metal-organic frameworks (MOFs), and probes for biochemical research.
• Peptidomimetics: Integral component in the design and synthesis of peptide analogs and mimetics for medicinal chemistry applications.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in stereoselective chemical transformations.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals and performance materials.

Basic Information

Product Name	1H-Imidazole-2-Propanoic Acid, α-Hydroxy-
CAS No.	958808-92-9
Molecular Formula	C₆H₈N₂O₃
Molecular Weight	156.14 g/mol
Synonyms	α-Hydroxy-1H-imidazole-2-propanoic acid; 2-(1H-Imidazol-2-yl)-2-hydroxypropanoic acid; (2-Hydroxy-2-(1H-imidazol-2-yl))acetic acid; 1H-Imidazole-2-propanoic acid, α-hydroxy-; Hydroxyimidazolepropanoic acid; 2-(Imidazol-2-yl)-2-hydroxyacetic acid; L-α-Hydroxyimidazole-2-propionic acid (enantiomer specific); Contact for additional trade names and abbreviations.
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-2-Propanoic Acid, α-Hydroxy- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (enantiomer-specific)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.