Description

{4-[4-(Trifluoromethoxy)Phenoxy]Phenyl}Boronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its molecular structure, featuring a trifluoromethoxy-substituted biphenyl ether core, is critical for developing compounds with enhanced metabolic stability and bioavailability. This boronic acid is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron reagent for forming carbon-carbon bonds to create complex biaryl structures in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides with improved efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and semiconductors.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	{4-[4-(Trifluoromethoxy)Phenoxy]Phenyl}Boronic Acid
CAS No.	958457-41-5
Molecular Formula	C13H10BF3O4
Molecular Weight	298.03 g/mol
Synonyms	4-[4-(Trifluoromethoxy)phenoxy]benzeneboronic acid; [4-[4-(Trifluoromethoxy)phenoxy]phenyl]boronic acid; 4'-(Trifluoromethoxy)[1,1'-biphenyl]-4-ylboronic acid; B-[4-[4-(Trifluoromethoxy)phenoxy]phenyl]boronic acid; (4-(4-(Trifluoromethoxy)phenoxy)phenyl)boronic acid; 958457-41-5; Boronic acid, B-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-
EINECS	Contact for details

Quality Control

Our {4-[4-(Trifluoromethoxy)Phenoxy]Phenyl}Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.