Description

(2-Bromo-3-Fluoro-Phenyl)-Acetic Acid is a high-purity fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional halogenated structure, which provides two distinct reactive handles for selective cross-coupling and functionalization reactions. Pharmaceutical, agrochemical, and advanced material researchers need it for the development of novel active ingredients and specialty chemicals, where its specific substitution pattern is critical for modulating biological activity and material properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides, where the fluorine and bromine atoms can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis, enabling more efficient and selective synthetic transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials that require specific halogenated aromatic units.
• Chemical Biology Probes: Useful for synthesizing tagged molecules and probes used to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	(2-Bromo-3-Fluoro-Phenyl)-Acetic Acid
CAS No.	958454-33-6
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	2-(2-Bromo-3-fluorophenyl)acetic acid; (2-Bromo-3-fluorophenyl)acetic Acid; 2-Bromo-3-fluorobenzeneacetic acid; α-(2-Bromo-3-fluorophenyl)acetic acid; o-Bromo-m-fluorophenylacetic acid; 958454-33-6; (2-Br-3-F-Ph)-CH2COOH
EINECS	Contact for details

Quality Control

Our (2-Bromo-3-Fluoro-Phenyl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with relevant regulatory frameworks for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.