Description

2-Fluoro-3-Oxo-3-Phenylpropionic Acid Ethyl Ester is a high-purity fluorinated β-keto ester building block, essential for synthesizing complex molecules in advanced research and development. Its unique structure, featuring both a fluorine atom and a reactive keto-ester group, makes it a versatile intermediate for introducing fluorinated motifs, which are critical for modulating the biological activity and physicochemical properties of target compounds. This product is primarily utilized by pharmaceutical, agrochemical, and advanced material scientists engaged in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated heterocycles, active pharmaceutical ingredients (APIs), and prodrugs, leveraging fluorine's ability to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and target binding.
• Material Science Research: Serves as a precursor for fluorinated monomers or additives in the development of specialty polymers, coatings, and liquid crystals with tailored properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging, diagnostics, and studying biological mechanisms.
• Organic Synthesis Building Block: Utilized in various name reactions, such as Claisen condensations or Michael additions, to construct complex, fluorinated organic frameworks in medicinal and process chemistry.

Basic Information

Product Name	2-Fluoro-3-Oxo-3-Phenylpropionic Acid Ethyl Ester
CAS No.	1479-22-7
Molecular Formula	C11H11FO3
Molecular Weight	210.20 g/mol
Synonyms	Ethyl 2-Fluoro-3-oxo-3-phenylpropanoate; Ethyl 2-Fluoro-3-oxo-3-phenylpropionate; 3-Phenyl-2-fluoromalonic Acid Monoethyl Ester; 2-Fluoro-3-oxo-3-phenyl-propionic Acid Ethyl Ester; β-Fluoro-β-oxohydrocinnamic Acid Ethyl Ester; Ethyl (2-Fluoro-3-oxo-3-phenyl)propionate; 1479-22-7; NSC 404083
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Oxo-3-Phenylpropionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in cGMP-compliant research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.