Description

L-4-Fluorophenylalanine is a fluorinated derivative of the essential amino acid phenylalanine, where a fluorine atom is substituted at the para position of the aromatic ring. This structural modification makes it a crucial non-natural amino acid building block in pharmaceutical research and development. It is primarily utilized in the synthesis of peptides and peptidomimetics, serving researchers and manufacturers in the life sciences sector. The compound's unique properties facilitate the study of protein structure, function, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Incorporated into peptide sequences to enhance metabolic stability, modulate bioavailability, and study structure-activity relationships (SAR).
• Proteomics & Biochemical Research: Used as a tool compound for labeling, protein engineering, and enzyme inhibition studies.
• Radiopharmaceuticals: Serves as a precursor for 18F-labeled compounds used in Positron Emission Tomography (PET) imaging.
• Agrochemical Research: Employed in the development of novel herbicides and pesticides with optimized properties.

Basic Information

Product Name	L-4-Fluorophenylalanine
CAS No.	1132-68-9
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	(S)-2-Amino-3-(4-fluorophenyl)propanoic acid; L-p-Fluorophenylalanine; FPA; 4-Fluoro-L-phenylalanine; (S)-4-Fluorophenylalanine; L-4-FPhe; H-Phe(4-F)-OH; L-β-(4-Fluorophenyl)alanine
EINECS	214-483-6

Quality Control

Our L-4-Fluorophenylalanine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (typically ≥98% by HPLC), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in 1N HCl)
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.