Description

α-Fluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid group and a fluorine atom on the phenyl ring, makes it a critical intermediate for creating compounds with enhanced biological activity and metabolic stability. This high-purity chemical is essential for research and production within the pharmaceutical, agrochemical, and material science industries, where precise molecular modification is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), protease inhibitors, and other active pharmaceutical ingredients (APIs) where the fluorine atom modulates potency and pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, leveraging the fluorine substituent to improve lipophilicity and target binding.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, crucial for producing enantiomerically pure compounds.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorinated characteristics.
• Peptide Mimetics and Bio-conjugation: The carboxylic acid functionality allows for coupling to amines, making it useful for creating peptide analogs and diagnostic probes.
• Chemical Biology Probes: Acts as a starting material for fluorinated probes and tags used in imaging and mechanistic studies within life sciences.

Basic Information

Product Name	α-Fluorophenylacetic Acid
CAS No.	1578-63-8
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	(2-Fluorophenyl)acetic Acid; 2-Fluorobenzeneacetic Acid; 2-Fluorophenylacetic Acid; o-Fluorophenylacetic Acid; α-Fluorophenylacetic Acid; 2-Fluorophenylethanoic Acid; NSC 404058; FPA
EINECS	Contact for details

Quality Control

Our α-Fluorophenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.