Description

2-Fluoro-6-(Methylthiomethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a unique fluorinated and thioether-substituted aromatic ring. This structure makes it a valuable and versatile building block in modern synthetic chemistry, particularly for cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures. The compound's reactivity profile allows for the precise introduction of functionalized phenyl groups into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron reagent for forming carbon-carbon bonds with aryl halides, enabling the construction of biaryl systems common in drug molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and sulfur motifs for bioactivity.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for catalysts or monomers for conductive polymers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring this specific boronic acid derivative.

Basic Information

Product Name	2-Fluoro-6-(Methylthiomethoxy)Phenylboronic Acid
CAS No.	958454-13-2
Molecular Formula	C8H10BFO3S
Molecular Weight	216.04 g/mol
Synonyms	(2-Fluoro-6-((methylthio)methoxy)phenyl)boronic acid; 2-Fluoro-6-[(methylsulfanyl)methoxy]benzeneboronic acid; B-[2-Fluoro-6-[(methylthio)methoxy]phenyl]boronic acid; 958454-13-2; 2-Fluoro-6-(methylthiomethoxy)benzeneboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(Methylthiomethoxy)Phenylboronic Acid undergoes rigorous analytical testing to ensure high purity and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.