Description

4-(2,2-Difluoroethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a difluoroethoxy-substituted phenyl ring, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for forming carbon-carbon bonds. This high-purity boronic acid is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where the introduction of fluorine-containing motifs is desired to modulate the properties of target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring fluorinated ether linkages to enhance metabolic stability, bioavailability, or binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the difluoroethoxy group can improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or building block for synthesizing novel organic electronic materials, such as those used in OLEDs or semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis or as a model substrate for testing new catalytic systems in cross-coupling reactions.
• Chemical Biology & Probe Synthesis: Utilized to create molecular probes and bioconjugates for studying biological processes, leveraging the boronic acid group's ability to interact with diols.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-(2,2-Difluoroethoxy)Phenylboronic Acid
CAS No.	958453-65-1
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	[4-(2,2-Difluoroethoxy)phenyl]boronic acid; 4-(2,2-Difluoroethoxy)benzeneboronic acid; B-[4-(2,2-Difluoroethoxy)phenyl]boronic acid; (4-(2,2-Difluoroethoxy)phenyl)boronic acid; 958453-65-1; 4-(Difluoroethoxyl)phenylboronic Acid; 4-(2,2-Difluoroethoxy)phenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Our 4-(2,2-Difluoroethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Heavy Metals	<20 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.