Description

4-(3,4,4-Trifluoro-But-3-En-1-Yl-Oxy)-Phenylboronic Acid is a specialized organoboron compound featuring a unique trifluoroalkenyl ether linker attached to a phenylboronic acid core. This structure is critical for its role as a versatile building block in advanced organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel, fluorinated active ingredients. The compound's design enables the introduction of both the phenylboronic acid moiety and a reactive, fluorinated alkene group into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex, fluorinated molecules in drug discovery and development, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for synthesizing advanced polymers and liquid crystals with specific electronic or optical properties.
• Suzuki-Miyaura Cross-Coupling: Functions as a pivotal boronic acid partner for forming carbon-carbon bonds, enabling the modular assembly of complex biaryl and heterobiaryl structures.
• Fluorine Chemistry Exploration: Essential for academic and industrial research focused on incorporating trifluoroalkenyl groups into organic frameworks to modulate lipophilicity and metabolic stability.
• Chemical Biology Probes: Can be utilized to develop fluorinated probes for studying biological processes and protein-ligand interactions.

Basic Information

Product Name	4-(3,4,4-Trifluoro-But-3-En-1-Yl-Oxy)-Phenylboronic Acid
CAS No.	958453-62-8
Molecular Formula	C10H8BF3O3
Molecular Weight	244.0 g/mol
Synonyms	4-[(3,4,4-Trifluorobut-3-en-1-yl)oxy]benzeneboronic Acid; [4-[(3,4,4-Trifluoro-3-buten-1-yl)oxy]phenyl]boronic Acid; 4-(3,4,4-Trifluorobut-3-enyloxy)phenylboronic Acid; 4-(3,4,4-Trifluoro-but-3-en-1-yloxy)benzeneboronic Acid; 958453-62-8; B-[4-[(3,4,4-Trifluoro-3-buten-1-yl)oxy]phenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 4-(3,4,4-Trifluoro-But-3-En-1-Yl-Oxy)-Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to minimize exposure to moisture and oxygen, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.