Description

3-(2,2-Difluoroethoxy)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing difluoroalkoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its boronic acid group facilitates precise molecular assembly.
• Ligand and Catalyst Development: Serves as a starting material for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the construction of molecular probes and sensors for studying biological processes due to its selective reactivity.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs working on client-specific molecular targets.

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Phenylboronic Acid
CAS No.	958452-33-0
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	[3-(2,2-Difluoroethoxy)phenyl]boronic acid; (3-(2,2-Difluoroethoxy)phenyl)boronic acid; 3-(2,2-Difluoroethoxy)benzeneboronic acid; Boronic acid, B-[3-(2,2-difluoroethoxy)phenyl]-; 958452-33-0; 3-(Difluoroethoxyphenyl)boronic Acid; 3-(2,2-Difluoroethoxy)phenyl-B(OH)2
EINECS	Contact for details

Quality Control

Every batch of 3-(2,2-Difluoroethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.