Description

2-(2,2-Difluoroethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a difluoroethoxy substituent on the phenyl ring, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecules. This high-purity boronic acid is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing difluoroalkyl ether motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers and functional materials.
• Suzuki-Miyaura Cross-Coupling: A fundamental reagent for forming carbon-carbon bonds between aryl halides and this boronic acid derivative.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Life Sciences Research: Utilized as a biochemical probe or in the synthesis of compounds for biological screening and diagnostic applications.

Basic Information

Product Name	2-(2,2-Difluoroethoxy)Phenylboronic Acid
CAS No.	958452-29-4
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	[2-(2,2-Difluoroethoxy)phenyl]boronic acid; 2-(2,2-Difluoroethoxy)benzeneboronic acid; (2-(2,2-Difluoroethoxy)phenyl)boronic acid; Boronic acid, B-[2-(2,2-difluoroethoxy)phenyl]-; 958452-29-4; 2-(Difluoroethoxy)phenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-(2,2-Difluoroethoxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.