Description

5-Trifluoromethyl-Thiophene-2-Boronic Acid is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecules for advanced material and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing trifluoromethylated heterocycles.
• Agrochemical Synthesis: Used in the research and development of advanced active ingredients, leveraging the thiophene and trifluoromethyl motifs for enhanced biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, organic semiconductors, and liquid crystals with tailored electronic properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for diagnostic and biochemical research applications.
• Catalyst Ligand Synthesis: Acts as a starting material for the preparation of specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in client-directed synthesis projects requiring specific boronic acid derivatives.

Basic Information

Product Name	5-Trifluoromethyl-Thiophene-2-Boronic Acid
CAS No.	958451-91-7
Molecular Formula	C5H4BF3O2S
Molecular Weight	195.96 g/mol
Synonyms	2-Borono-5-(trifluoromethyl)thiophene; (5-(Trifluoromethyl)thiophen-2-yl)boronic acid; 5-(Trifluoromethyl)-2-thienylboronic acid; 5-(Trifluoromethyl)thiophene-2-boronic Acid; Thiophene-2-boronic acid, 5-(trifluoromethyl)-; 958451-91-7; 2-Thienylboronic acid, 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Thiophene-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.