Description

2-Difluoromethoxy-3-Methyl-Benzeneboronic Acid is a specialized organoboron building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. This compound is valued for its role in constructing complex molecular architectures, enabling the development of advanced materials and active pharmaceutical ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with enhanced properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those requiring the difluoromethoxy and methyl-substituted benzene core.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where precise molecular structure dictates material properties.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Difluoromethoxy-3-Methyl-Benzeneboronic Acid
CAS No.	958451-78-0
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	(2-Difluoromethoxy-3-methylphenyl)boronic acid; 3-Methyl-2-(difluoromethoxy)benzeneboronic acid; 2-(Difluoromethoxy)-3-methylbenzeneboronic acid; Boronic acid, B-[2-(difluoromethoxy)-3-methylphenyl]-; 958451-78-0; 2-Difluoromethoxy-3-methylphenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Difluoromethoxy-3-Methyl-Benzeneboronic Acid is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our standard grade meets typical research and development requirements, with comprehensive analysis performed via HPLC, NMR, and other spectroscopic techniques. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.