Description

2-Difluoromethoxy-5-Trifluoromethyl-Benzeneboronic Acid is a high-purity, multi-fluorinated boronic acid derivative essential for modern synthetic chemistry. Its unique structure makes it a critical building block for constructing complex molecules, particularly in the development of advanced materials and active pharmaceutical ingredients. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Material Development: Incorporated into the synthesis of fluorinated organic molecules for electronic displays and lighting applications due to its stability and electronic properties.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the creation of specialty polymers with specific thermal, chemical, or surface properties.
• Chemical Biology & Proteomics: Utilized as a handle for bioconjugation and in the development of enzyme inhibitors or molecular probes.

Basic Information

Product Name	2-Difluoromethoxy-5-Trifluoromethyl-Benzeneboronic Acid
CAS No.	958451-77-9
Molecular Formula	C8H6BF5O3
Molecular Weight	255.94 g/mol
Synonyms	2-(Difluoromethoxy)-5-(trifluoromethyl)benzeneboronic Acid; (2-(Difluoromethoxy)-5-(trifluoromethyl)phenyl)boronic Acid; 5-Trifluoromethyl-2-difluoromethoxybenzeneboronic Acid; 2-Difluoromethoxy-α,α,α-trifluoro-p-tolueneboronic Acid; Boronic acid, B-[2-(difluoromethoxy)-5-(trifluoromethyl)phenyl]-; 958451-77-9; 2-Difluoromethoxy-5-Trifluoromethylphenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Difluoromethoxy-5-Trifluoromethyl-Benzeneboronic Acid is manufactured and tested under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.